Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action
نویسندگان
چکیده
منابع مشابه
Sublingual immunotherapy in allergic rhinitis
Current treatment options for allergic rhinitis (AR) include allergen avoidance and environmental control, pharmacotherapy, nasal surgery and immunotherapy. Among these, immunotherapy is the only therapeutic option that modifies fundamental immunologic mechanism by inducing desensitization. Specific allergen immunotherapy has been used for 1 century since 1911 and subcutaneous immunotherapy (SC...
متن کاملSublingual allergen immunotherapy: mode of action and its relationship with the safety profile.
Allergen immunotherapy reorients inappropriate immune responses in allergic patients. Sublingual allergen immunotherapy (SLIT) has been approved, notably in the European Union, as an effective alternative to subcutaneous allergen immunotherapy (SCIT) for allergic rhinitis patients. Compared with SCIT, SLIT has a better safety profile. This is possibly because oral antigen-presenting cells (most...
متن کاملCurrent issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis
Zorica ŽIVKOVIĆ Kneginje Zorke 9, 11000 Belgrade Serbia [email protected] SUMMARY In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be “promising route” for allergic desensitization. A few years later, the World Health Organization recommended this therapy as “a viable alternative to the i...
متن کاملHow does sublingual immunotherapy work?
There is now a growing consensus that specific sublingual immunotherapy (SLIT) does actually work. Initial skepticism about the results of uncontrolled or open studies has been removed after the positive outcomes of a series of large, double-blind, placebo-controlled trials. A recent meta-analysis found 21 trials of SLIT that were of sufficient quality to merit analysis of their efficacy agains...
متن کاملSublingual Immunotherapy in Children with Allergic Rhinitis
The prevalence of allergic disease has been increasing over time and now represents a global health problem. For example, allergic disease in the UK affects up to 40% of children with allergic rhinitis accounting for a significant component of the allergic burden. There is also specific evidence for increasing prevalence of allergic rhinitis in the UK paediatric population, particularly among y...
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ژورنال
عنوان ژورنال: Pathogens
سال: 2021
ISSN: 2076-0817
DOI: 10.3390/pathogens10020147